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Title: Dr. Job Title: Egenis Research Fellow Tel: 01392 269148 Fax: 01392 264676 Email: M.Grote@exeter.ac.uk Building: Byrne House, Streatham Campus, University of Exeter Room Number: FF11
I have a background in both philosophy and science. After I had obtained a Magister Artium (M.A.) of philosophy and biology at Humboldt-University of Berlin in 2004, I decided to work in experimental science and started a project in membrane biology. Through my laboratory work, I became interested in the history and epistemology of science and changed disciplines after I had received a doctorate from the Institute of Biology at Humboldt-University in 2008. In 2009, I began postdoctoral research on a two-year collaboration between Hans-Jörg Rheinberger's department at the Max Planck Institute for the History of Science in Berlin and Egenis, spending a year working at each institution. The project I am undertaking in Egenis throughout 2010 is Microbial rhodopsin research in translation: Discovery, laboratory models and innovative applications.
I am interested in the roles experimentation and materiality plays in science. In this respect, membrane biology is an auspicious and mostly unexplored example. Both its history and contemporary studies provide insights into the often underestimated relation of concepts and practices from chemistry and biological research. This field displays another characteristic that is typical for the life sciences – and presumably science in general: Closely knit material, conceptual and personal networks between scientific and other cultural activities such as the use of natural resources, trade or technological developments. Moreover, the study of membrane biology could provide an entry point to an epistemology of surfaces, spaces and movements in science.
Grote M. (forthcoming), Surfaces of action. Cells and membranes in electrochemistry and the life sciences, Studies in the History and Philosophy of Science Part C: Biology and the Biomedical Sciences Grote M. (2008), Hybridizing bacteria, crossing methods, cross-checking arguments: The transition from episomes to plasmids (1961-1969), History and Philosophy of the Life Sciences 30: 407-430 Grote, M. (2007), Die "Kräfte des Organischen". Transformationen des Naturbildes in C.F. Kielmeyers Karlsschulrede, Verhandlungen zur Geschichte und Theorie der Biologie 13: 165-175
Grote M., Polyhach Y., Jeschke G., Steinhoff H.-J., Schneider E. and Bordignon E. (2009), Transmembrane signaling in the maltose ABC transporter MalFGK2-E: Periplasmic MalF-P2 loop communicates substrate availability to the ATP-bound MalK dimer, Journal of Biological Chemistry 284: 17521-17526
Jacso T., Grote M., Schmieder P., Schneider E. and Reif B. (2009), NMR assignments of the periplasmatic loop P2 of the MalF subunit of the maltose ATP binding cassette transporter, Biomolecular NMR assignments 3: 21-3
Jacso T., Grote M., Daus M.L., Schmieder P., Keller S., Schneider E. and Reif B. (2009) The periplasmic loop P2 of the MalF subunit of the maltose ATP binding cassette transporter is sufficient to bind the maltose binding protein MalE. Biochemistry 48: 2216-2225
Daus M.L., Grote M. and Schneider E. (2009), The MalF-P2 loop of the ATP-binding cassette transporter MalFGK2 from Escherichia coli and Salmonella enterica serovar typhimurium interacts with maltose binding protein (MalE) throughout the catalytic cycle, Journal of Bacteriology 191: 754-761
Grote M.*, Bordignon E.*, Polyhach Y., Jeschke G., Steinhoff H.-J. and Schneider E. (2008), A comparative EPR study of the nucleotide-binding domains’ catalytic cycle in the assembled maltose ABC-importer. Biophysical Journal 95: 2924-2938
Daus M.L.*, Grote M.*, Müller P., Doebber M., Herrmann A., Steinhoff H.J. and Schneider E. (2007), ATP-driven MalK dimer closure and re-opening and conformational changes of the 'EAA'-motifs are crucial for function of the maltose ATP-binding-cassette transporter (MalFGK2). Journal of Biological Chemistry 282: 22387-22396 *shared first authorship
Workshop Membranes, Surfaces and Boundaries – interstices in the history of science, technology and culture. Workshop at the Max Planck Institute for the History of Science, Berlin. October 7th-9th, 2010. Organized by Mathias Grote, Laura Otis and Max Stadler.
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