SpeakersProfessor Jonathan Frampton, Institute of Biomedical Research, University of Birmingham
University of Exeter,Egenis, Byrne House,St Germans Road,Exeter, EX4 4PJ
Room no: GF7, Byrne House
Time: 3:30 - 5:00 PM
"Stem cell regulation by Myb family proteins: A story of investigation into a paradigm shaped largely by serendipity"Myb family proteins were first identified through their involvement in various stages of blood cell formation, in particular because a mutated version of one variant carried by a virus was found to cause leukaemia in chickens. The biological importance of Myb proteins, which act to regulate the expression of specific sets of genes, was eventually found to be widespread. My groups research has become focussed on the involvement of Myb proteins in the regulation of the key features of stem cells, namely their ability to self-renew while at the same time retaining the capacity to undergo controlled differentiation towards one or more specialised cell types. The overall approach taken in my laboratory involves investigation of the consequences of reduced expression of Myb proteins through the use of genetic modification in mice. Some of the more significant findings will be described. These will include the discovery that the c-Myb protein regulates blood stem cell differentiation and in so doing normally prevents the development of uncontrolled myeloproliferation, which is characteristic of a group of quite common human haematological diseases. Also, some very recent findings will be discussed that appear to demonstrate that in embryonic stem cells the B-Myb protein protects against genomic instability; a feature that is likely to have considerable significance in the application of these cells in regenerative medicine.